Publications
For a complete list, please visit https://scholar.google.com/citations?user=Rspedx8AAAAJ&hl=en
Publications since 2025
2026
Philippi, M., Dohle, J., Watrinet, I., Holtmannspötter, M., Miao, Y., Li, J., ... & You, C. (2026). Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes. Science Signaling, 19(927), eadr8141.
2025
Wang, J., Wang, J., Miao, Y., Li, Y., Zhu, S., Zhang, Y., ... & Südhof, T. C. (2025). BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands. Nature Communications.
Miao, Y.#, Wang, H., Jude, K. M., Wang, J., Wang, J., Wernig, M., & Südhof, T. C.# (2025). Structure of the complex of C1q-like 3 protein with adhesion-GPCR BAI3. Communications Biology, 8(1), 693. (#corresponding authors)
Miao, Y.*, Yadav, V.*, Shadrick, W., Liu, J., Jenner, A. R., Nichols, C. B., ... & Washington, E. J. (2025). Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways. mBio, e01795-25. (*These authors contribute equally)
Mu, Q., Ha, A., Santos, A. J., Lo, Y. H., van Unen, V., Miao, Y., ... & Kuo, C. J. (2025). FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response. Developmental cell, 60(3), 342-351.
Representative publications 2010-2024
Wang, J.*, Miao, Y.*, Wicklein, R., Sun, Z., Wang, J., Jude, K. M., ... & Südhof, T. C. (2021). RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184(24), 5869-5885. (*These authors contribute equally)
Miao, Y., Ha, A., de Lau, W., Yuki, K., Santos, A. J., You, C., ... & Garcia, K. C. (2020). Next-generation surrogate Wnts support organoid growth and deconvolute frizzled pleiotropy in vivo. Cell Stem Cell, 27(5), 840-851.
Luca, V. C.*, Miao, Y.*, Li, X., Hollander, M. J., Kuo, C. J., & Garcia, K. C. (2020). Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling. PLoS One, 15(1), e0226928. (*These authors contribute equally)
Dang, L. T.*, Miao, Y.*, Ha, A., Yuki, K., Park, K., Janda, C. Y., ... & Baker, D. (2019). Receptor subtype discrimination using extensive shape complementary designed interfaces. Nature Structural & Molecular Biology, 26(6), 407-414. (*These authors contribute equally).
Miao, Y., Tenor, J. L., Toffaletti, D. L., Maskarinec, S. A., Liu, J., Lee, R. E., ... & Brennan, R. G. (2017). Structural and in vivo studies on trehalose-6-phosphate synthase from pathogenic fungi provide insights into its catalytic mechanism, biological necessity, and potential for novel antifungal drug design. mBio, 8(4), 10-1128.
Miao, Y., Tenor, J. L., Toffaletti, D. L., Washington, E. J., Liu, J., Shadrick, W. R., ... & Brennan, R. G. (2016). Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. Proceedings of the National Academy of Sciences, 113(26), 7148-7153.
Other publications (2010-2024)
Funa, N. S., Mjoseng, H. K., de Lichtenberg, K. H., Raineri, S., Esen, D., la Rosa Egeskov-Madsen, A., ... Miao, Y., ... & Serup, P. (2024). TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling. Stem Cell Reports, 19(7), 973-992.
Tsutsumi, N., Hwang, S., Waghray, D., Hansen, S., Jude, K. M., Wang, N., Miao, Y., ... & Garcia, K. C. (2023). Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination. Proceedings of the National Academy of Sciences, 120(11), e2218238120.
Philippi, M., Richter, C. P., Kappen, M., Watrinet, I., Miao, Y., Runge, M., ... & You, C. (2022). Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co‐Condensation of Wnt Signalodroplets. Small, 18(50), 2203723.
Yu, Q. C., Geng, A., Preusch, C. B., Chen, Y., Peng, G., Xu, Y., … Miao, Y., ... & Zeng, Y. A. (2022). Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry. Cell Reports, 41(8).
Maimets, M., Pedersen, M. T., Guiu, J., Dreier, J., Thodberg, M., Antoku, Y., ... Miao, Y., …& Jensen, K. B. (2022). Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling. Nature Communications, 13(1), 715.
Tsutsumi, N., Mukherjee, S., Waghray, D., Janda, C. Y., Jude, K. M., Miao, Y., ... & Garcia, K. C. (2020). Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. elife, 9, e58464.
Buikema, J. W., Lee, S., Goodyer, W. R., Maas, R. G., Chirikian, O., Li, G., Miao, Y., ... & Wu, S. M. (2020). Wnt activation and reduced cell-cell contact synergistically induce massive expansion of functional human iPSC-derived cardiomyocytes. Cell stem cell, 27(1), 50-63.
Pleguezuelos-Manzano, C., Puschhof, J., Huber, A. R., van Hoeck, A.,... Miao, Y., … Clevers, H. (2020) Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature, 580(7802), 269-273.
Gbenedio, O. M., Bonnans, C., Grun, D., Wang, C. Y., Hatch, A. J., Mahoney, M. R., ... Miao, Y., … & Depeille, P. (2019). RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer. JCI insight, 4(15), e127552.
Mohan, K., Ueda, G., Kim, A. R., Jude, K. M., Fallas, J. A., Guo, Y., ... Miao, Y., … & Garcia, K. C. (2019). Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364(6442), eaav7532.
Vallon, M., Yuki, K., Nguyen, T. D., Chang, J., Yuan, J., Siepe, D., Miao, Y., ... & Kuo, C. J. (2018). A RECK-WNT7 receptor-ligand interaction enables isoform-specific regulation of Wnt bioavailability. Cell reports, 25(2), 339-349.
Perfect, J. R., Tenor, J. L., Miao, Y., & Brennan, R. G. (2017). Trehalose pathway as an antifungal target. Virulence, 8(2), 143-149.
Wu, Y., Lou, Z., Miao, Y., Yu, Y., Dong, H., Peng, W., ... & Rao, Z. (2010). Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein & cell, 1(5), 491-500.